Molecular biology of enhancer RNAs: Defining how eRNA processing, stability, localisation and molecular interactions govern their functions, particularly in post-transcriptional regulation. [paper]
Silencers and regulatory DNA: Identifying distal silencer elements through transcriptional and chromatin accessibility dynamics, and testing their regulatory functions experimentally. [paper]
Noncoding RNA function and genetic variation: Investigating noncoding RNA regulatory networks and integrating molecular evidence with computational and AI models to interpret noncoding variants in health and disease. [paper]
Cancer: Investigating eRNA processing, long noncoding RNA function and regulatory noncoding mutations in ovarian cancer and squamous cell carcinoma, including their roles in post-transcriptional regulation, mechanical memory, metastasis and disease progression. [paper]
Age-related macular degeneration: Investigating eRNA dysregulation and mechanoresponsive post-transcriptional networks, including their potential roles in pathological mechanical memory and retinal disease. [paper]