Born at the Enhancer, Defined by Function

Sun, 04 Oct 2026 00:00:00 +0100

An enhancer tells us where an RNA is produced, but not what it becomes. The emerging evidence suggests it is time to follow the RNA itself.

Contact

Mon, 01 Jan 0001 00:00:00 +0000

Research enquiries
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School of Health
Leeds Beckett University, PD511, Portland Building
City Campus, Leeds LS1 3HE

Chinedu A. Anene

Group

Mon, 01 Jan 0001 00:00:00 +0000

Principal Investigator
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Chinedu A. Anene · ORCID

PhD students
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Rene Kuklinkova

Characterisation of Senescent Cells across Human Tissues and Lifespan

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Natalia Benova

Identification and Characterisation of Regulatory Noncoding Mutations in Ovarian Cancer

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Emanuela Ibenye

Mapping the Post-Transcriptional Regulatory Landscape of Enhancer RNAs in Cellular Homeostasis: Mechanisms of eRNA Regulation in Normal Physiology

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Chukwu Chibuike Victor

Enhancer RNA Processing in Squamous Cell Carcinoma Development and Progression: Functional Roles and Therapeutic Potential

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Sunday Nweke Egwu

Identifying Distal Silencer Elements from Transcriptional and Chromatin Accessibility Dynamics with In-Vitro Functional Validation

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Kingsley Anya

Modelling Post-Transcriptional Enhancer RNA Function through Foundational AI Models for Rare Genetic Disease Interpretation

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Okechukwu Emmanuel Akwa

Modelling Post-Transcriptional Long Noncoding RNA Function for Prioritisation of Noncoding Mutations in Squamous Cell Carcinoma

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Opportunities in AneneLab

Mon, 01 Jan 0001 00:00:00 +0000

We welcome enquiries from people interested in our research.

Current vacancies
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There are no funded vacancies currently advertised.

Research themes and selected papers

Mon, 01 Jan 0001 00:00:00 +0000

Molecular biology of enhancer RNAs: Defining how eRNA processing, stability, localisation and molecular interactions govern their functions, particularly in post-transcriptional regulation. [paper]

Silencers and regulatory DNA: Identifying distal silencer elements through transcriptional and chromatin accessibility dynamics, and testing their regulatory functions experimentally. [paper]

Tools and resources

Mon, 01 Jan 0001 00:00:00 +0000

Our software and resources support computational genomics, regulatory biology and data analysis, from enhancer RNA research to broader bioinformatics workflows.

eRNAkit
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eRNAkit brings together annotations, datasets and computational tools for investigating enhancer RNA biology.

Regulatory DNA and RNA function in health and disease on Anene Lab

Born at the Enhancer, Defined by Function

Contact

Research enquiries #

Group

Principal Investigator #

PhD students #

Rene Kuklinkova

Natalia Benova

Emanuela Ibenye

Chukwu Chibuike Victor

Sunday Nweke Egwu

Kingsley Anya

Okechukwu Emmanuel Akwa

Opportunities in AneneLab

Current vacancies #

Research themes and selected papers

Tools and resources

eRNAkit #

Research enquiries
#

Principal Investigator
#

PhD students
#

Current vacancies
#

eRNAkit
#